Prostaglandin E₂ and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammation

Abstract

Increased airway concentrations of PGE(2) are consistent with the hypothesis that PGE(2) has a bronchoprotective and anti-inflammatory role in patients with more severe asthma. A reduced PGE(2) to cysLT ratio in the airways may adversely affect lung function and contribute to persistence of symptoms and airway remodelling in patients with eosinophilic airway inflammation.