The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

Specific Genetic Interference, Natural Sciences, Genetics +9

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Rosalind C. Lee, Rhonda Feinbaum, Victor Ambros · Cell · 1993 · 12.7K citations · Full text

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Brenda J. Reinhart, Frank J. Slack, Michael Basson et al. · Nature · 2000 · 4.9K citations

Developmental Timing, Developmental Biology, Genetics +6

Identification of Novel Genes Coding for Small Expressed RNAs

Mariana Lagos‐Quintana, Reinhard Rauhut, Winfried Lendeckel et al. · Science · 2001 · 4.9K citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

Emily Bernstein, Amy A. Caudy, Scott M. Hammond et al. · Nature · 2001 · 4.9K citations

Rna Interference, Genetics, Natural Sciences +12