Concepedia

Preoperative<i>GNAS</i>and<i>KRAS</i>Testing in the Diagnosis of Pancreatic Mucinous Cysts

Aatur D. Singhi, Marina N. Nikiforova, Kenneth Fasanella, Kevin M. McGrath, Reetesh K. Pai, N. Paul Ohori, Tanner Bartholow, Randall E. Brand, Jennifer Chennat, Xuong Lu,

Clinical Cancer Research · 2014 · 200 citations · 18 references

DOI

Abstract

The combination of GNAS and KRAS testing was highly specific and sensitive for IPMNs; however, the lack of sensitivity for MCNs highlights the need for additional markers to improve the detection of pancreatic mucinous neoplasms.

References

18

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

Masao Tanaka, Carlos Fernández-del Castillo, Volkan Adsay et al. · Pancreatology · 2012 · 2.3K citations

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Prevalence of Unsuspected Pancreatic Cysts on MDCT

Thomas A. Laffan, Karen M. Horton, Alison P. Klein et al. · American Journal of Roentgenology · 2008 · 861 citations · Full text

Recurrent <i>GNAS</i> Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Jian Wu, Hanno Matthaei, Anirban Maitra et al. · Science Translational Medicine · 2011 · 770 citations · Full text

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Mitsuro Kanda, Hanno Matthaei, Jian Wu et al. · Gastroenterology · 2012 · 700 citations

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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

Jian Wu, Yuchen Jiao, Marco Dal Molin et al. · Proceedings of the National Academy of Sciences · 2011 · 632 citations · Full text