THE EFFECT OF CORTICOTROPIN, CHORIONIC GONADOTROPIN AND TESTOSTERONE PROPIONATE ON URINARY ESTRADIOL-17β, ESTRONE AND ESTRIOL OF HUMAN SUBJECTS WITH PREVIOUS MYOCARDIAL INFARCTION*

Abstract

Administration of corticotropin (ACTH), chorionic gonadotropin or testosterone propionate to patients with and without previous myocardial infarction resulted in increased excretion of urinary estrone, estradiol-17β and estriol. The 7 control subjects and the 12 myocardial infarction patients responded to the injection of ACTH by excreting proportionately more estrone than estradiol or estriol. Both groups of patients responded to injection of testosterone propionate by excreting more estradiol than estrone or estriol. Of 12 myocardial infarction patients studied with ACTH, chorionic gonadotropin and testosterone propionate, only 2 responded by excreting more estriol than estrone.