Upregulation of<i>EphB2</i>and<i>ephrin-B2</i>at the Optic Nerve Head of DBA/2J Glaucomatous Mice Coincides with Axon Loss

Abstract

The expression of EphB2 and ephrin-B2 is upregulated at the ONH of glaucomatous DBA/2J mice coinciding with RGC axon loss. The direct binding of EphB2 and ephrin-B2 on adult RGC axons at the ONH and the ability of EphB2 to elevate intra-axonal calcium indicate that these proteins may affect RGC axon physiology in the setting of glaucoma and thus affect the development or progression of the disease.