Persistent Sacral Sensory Deficit Induced by Intrathecal Local Anesthetic Infusion in the Rat

Abstract

In the rat, restricted anesthetic distribution can be achieved, and sensory impairment may result. These findings further support an etiology of local anesthetic neurotoxicity for recent clinical injuries after continuous spinal anesthesia. The functional model described appears to be suitable for in vivo study of local anesthetic neurotoxicity.