Angewandte Chemie International Edition · 2002 · 34 citations · 0 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryNatural Product Drug DiscoveryAntimitotic ActivityAntimitotic DrugsChemical Synthesis Of AnaloguesNatural Product Total SynthesisTotal Synthesis-derived Analogues
Revision of the structure originally proposed for the antimitotic natural product diazonamide A (2) was required after the recent synthesis of polycycle (1); the total synthesis of 2 still remains elusive. However, there is much to learn from the significant synthetic contributions and innovative strategies developed to date.