Concepedia

Curcumin entrapped folic acid conjugated PLGA–PEG nanoparticles exhibit enhanced anticancer activity by site specific delivery

Jisha J. Pillai, Arun Kumar T. Thulasidasan, Ruby John Anto, Nandan C. Devika, N. Ashwanikumar, G. S. Vinod Kumar

RSC Advances · 2015 · 45 citations · 17 references

DOI

Concepts

Abstract

Herein we report curcumin entrapped nanoparticles of PLGA–PEG copolymer which were conjugated with folic acid (PPF copolymer) for site specific targeting since many cancer cells exhibit external folic acid binding receptors.

References

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Nanoparticle and targeted systems for cancer therapy

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

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Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery

Jianwei Guo, Xiaoling Gao, Lina Su et al. · Biomaterials · 2011 · 566 citations

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