Design, synthesis and evaluation of novel quinolinyl chalcones as antibacterial agents

Abstract

Some new substituted quinolinyl chalcones were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a microdilution procedure. Synthesized compounds 10a-g and 13h-q prove to be effective with MIC (mg ml -1 ), among them 10a, 10b, 10c, 13I, 13p showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1 H-NMR and elemental analysis.