Concepedia

Novel and Expeditious Microwave-Assisted Three-Component Reactions for the Synthesis of Spiroimidazolin-4-ones

Ye Ping, Katie Sargent, E. Theal Stewart, Jifeng Liu, Daniel Yohannes, Libing Yu

The Journal of Organic Chemistry · 2006 · 32 citations · 9 references

DOI

Concepts

Abstract

Highly efficient methods for the syntheses of spiroimidazolinones via microwave-assisted three-component one-pot sequential reactions or one-pot domino reactions are described. The efficiency and utility of the methods have been demonstrated by quickly accessing the antihypertensive drug irbesartan (2).

References

9

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Alexander Dömlingꝉ, Ivar Ugi · Angewandte Chemie International Edition · 2000 · 4K citations

Fast, easy, clean chemistry by using water as a solvent and microwave heating: the Suzuki coupling as an illustration

Nicholas E. Leadbeater · Chemical Communications · 2005 · 389 citations

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Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research for a Postdoctoral Fellowship (to I.R.B.), the BP endowment and the Novartis Research Fellowship (to S.V.L.), and Pharmacia & Upjohn (to C.P.).

Ian R. Baxendale, Steven V. Ley, Claudia Piutti · Angewandte Chemie International Edition · 2002 · 143 citations · Full text

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Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

Jifeng Liu, Jaekyoo Lee, Audra M. Dalton et al. · Tetrahedron Letters · 2005 · 136 citations

, , +1

A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists

C. BERNHART, Pierre Perreaut, B. Ferrari et al. · Journal of Medicinal Chemistry · 1993 · 108 citations · Full text

, , +12