Concepedia

Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion

Meng Sun, Chengfei Liu, Nagalakshmi Nadiminty, Wei Lou, Yezi Zhu, Joy C. Yang, Christopher P. Evans, Qinghua Zhou, Allen C. Gao

The Prostate · 2011 · 73 citations · 43 references

DOIFull text

Open access

Abstract

These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3.

References

43

Cancer Statistics, 2010

Ahmedin Jemal, Rebecca L. Siegel, Jiaquan Xu et al. · CA A Cancer Journal for Clinicians · 2010 · 12.6K citations · Full text

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Naftaly Meydan, T Grunberger, Harjit Dadi et al. · Nature · 1996 · 910 citations

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Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

Zhenglong Yuan, Yingjie Guan, Devasis Chatterjee et al. · Science · 2005 · 765 citations

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Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

James Turkson, Tammy Bowman, Roy Garcia et al. · Molecular and Cellular Biology · 1998 · 657 citations · Full text

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

Koichi Nakajima, Yojiro Yamanaka, Kazuto Nakae et al. · The EMBO Journal · 1996 · 582 citations · Full text

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