An Attempt to Map Two Genes for Tuberous Sclerosis Using Novel Two‐Point Methods^a

Abstract

There are several theoretical mechanisms by which a mutation at two or more distinct loci might give rise to clinically similar diseases, but relatively few examples have so far been found.The best chance of identifying such loci, if both are autosomal, exists when the mildness of the disorder allows the collection of large families or when candidate loci can be suggested for direct testing.An example of