Multicomponent Reactions for the Synthesis of Complex Piperidine Scaffolds

Abstract

Creating diversity: Multicomponent reactions for the synthesis of complex piperidine scaffolds lead to high levels of skeletal, functional, and stereochemical diversity in an efficient way (see scheme, X=OR, NR2). Connecting the acid chloride component to the dienophile generates polycyclic piperidine scaffolds by an intramolecular Diels–Alder reaction of the in situ generated azadienes. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.