Elevated levels of leukotriene C₄ synthase <scp>mRNA</scp> distinguish a subpopulation of eosinophilic oesophagitis patients

Abstract

Elevated oesophageal expression of LTC4 S mRNA is found in a subgroup of EoE patients, concomitant with higher serum IgE levels and an oesophageal transcriptome indicative of a more-pronounced allergic phenotype. Together with TSLP and IL-23 mRNA levels, oesophageal LTC4 S mRNA may facilitate diagnosis of an EoE subpopulation for personalized therapy.