Neocartilage Formation in 1 <i>g</i> , Simulated, and Microgravity Environments: Implications for Tissue Engineering

Abstract

Tissue cultivated on the RPM showed intermediate characteristics compared with ISS and 1 g conditions. These data indicate that the RPM system does not sustain microgravity. Although microgravity impacts the development of in vitro generated cartilage, simulated microgravity using the RPM may be a useful tool to produce cartilaginous tissue grafts with fewer cells.