Selective Monoformylation Of 1,3-Diaminopropane Derivatives

Abstract

Abstract A general procedure for regiospecific construction of N-aryl-N'-formyl-1,3-diaminopropanes 2 (R=H) by selective monoformylation of N-(3-aminopropyl)arylamines 1 is described. Compounds 1 are readily obtained with high yields by aminolysis of 3-bromopropylamine hydrobromide with aromatic amines. The present synthetic strategy was extended to the synthesis of other N-acyl-N-aryl-1,3 -diaminopropanes.