Conformations of γ‐Aminobutyric Acid (GABA): The Role of the n→π* Interaction

Abstract

Conformation confirmation: The nine conformers of the neurotransmitter γ-aminobutyric acid (GABA) identified in the gas phase can serve as a basis to represent the shape of GABA. An n→π* interaction guided by the Bürgi–Dunitz trajectory of nucleophilic addition is thought to be relevant in the stabilization of two of the folded conformers (gG1 and gG3 in the picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.