Concepedia

Reversible Hyperinsulinemic Hypoglycemia after Gastric Bypass: A Consequence of Altered Nutrient Delivery

Tracey McLaughlin, Marcia Peck, Jens J. Holst, Carolyn F. Deacon

The Journal of Clinical Endocrinology & Metabolism · 2010 · 181 citations · 20 references

DOIFull text

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Abstract

Post-RYGB hyperinsulinemia and hypoglycemia result entirely from altered nutrient delivery rather than generalized hyperfunction of beta-cells due to presurgical hypertrophy/hyperfunction or postsurgical nesidioblastosis. These findings support the use of GT for treatment of severe cases and have implications for surgical manipulations that may reverse/prevent this condition.

References

20

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Gang Xu, Doris A. Stoffers, Joel F. Habener et al. · Diabetes · 1999 · 1.2K citations

, , +19

Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

Cathrine Ørskov, L. Rabenhøj, André Wettergren et al. · Diabetes · 1994 · 885 citations

Hyperinsulinemic Hypoglycemia with Nesidioblastosis after Gastric-Bypass Surgery

Geoffrey J. Service, Geoffrey B. Thompson, F. John Service et al. · New England Journal of Medicine · 2005 · 781 citations · Full text

, , +13

Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets

Loredana Farilla, Angela Bulotta, Boaz Hirshberg et al. · Endocrinology · 2003 · 664 citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

Yazhou Li, Tanya Hansotia, Bernardo Yusta et al. · Journal of Biological Chemistry · 2002 · 588 citations · Full text