Drug Development and Industrial Pharmacy · 1993 · 17 citations · 6 references
PharmacyMedicinal ChemistryPharmacologyBioavailabilityDissolution TestingPharmaceutical FormulationDrug DispositionDrug DissolutionDrug Release From Dosage FormsDrug SolubilityFormulation Effects On DissolutionSolubility EnhancementBenzodiazepine TreatmentCoprecipitationCoprecipitation SynthesisCyclodextrin ComplexationCyclodextrin Inclusion ComplexesDissolution Rate AnalysisDissolution Rate DeterminationDrug Solubility Screening
AbstractThe preparation of an inclusion complex of Lorazepam, a benzodiazepine antianxiety agent with β -cyclodextrin is described. The inclusion compound was prepared by the homogeneous coprecipitation method in the molar ratio of 1:2 of the drug and β -cyclodextrin respectively. The formation of inclusion complex was evaluated by UV spectral studies, IR studies, X-ray diffractometry, and Differential Thermal Analysis. The solubility and in-vitro drug release studies indicated that the complex form of the drug significantly increase the solubility and the dissolution rate compared to the free form. Tablets prepared with Lorazepam- β -cyclodextrin complex also showed a significant increase in dissolution of the drug indicating that P-cyclodextrin plays an important role in the solubilization of the drug.
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