Antibacterial activity of alkaloids from Sida acuta

Abstract

Sida acuta is a shrub indigenous to pantropical regions. The
\nplant is widely used for its various pharmacological properties. Among
\ncompounds of pharmacological interest occurring in the plant, are
\nindoloquinoline alkaloids. The aim of the present study was to
\ninvestigate the antimicrobial activity of alkaloids of S. acuta from
\nBurkina Faso. The alkaloids had a good antimicrobial activity against
\nthe test microorganisms. In the agar-well diffusion assay, highest
\ninhibition zone diameters were recorded with Gram-positive bacteria.
\nThe broth microdilution assay gave minimal inhibitory concentration
\nvalues ranging from 16 to 400 μg/ml and minimal bactericidal
\nconcentration values ranging from 80 to up to 400 μg/ml. The gas
\nchromatography-mass spectrometry analysis of the same alkaloids led to
\nthe identification of cryptolepine and quindoline as the major
\ncomponents.