Divergent Synthesis of Sialylated Glycan Chains: Combined Use of Polymer Support, Resin Capture–Release, and Chemoenzymatic Strategies

Abstract

Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture–release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn=benzyl, TBS=tert-butyldimethylsilyl.