Infection and Immunity · 2006 · 100 citations · 16 references
Veterinary MedicineImmunologyInfectious DiseasesHost-pathogen InteractionsImmunology Of Infectious DiseasesParasite ImmunologyCell-mediated ImmunityCytotoxic T Lymphocyte ResponsesEffector T Cell FunctionHost-parasite Immune InteractionsImmune Responses To InfectionT Cell BiologyCd8 Positive T Cell ResponsesCellular Immune Response To ParasitesImmune KineticsT Cell Activation KineticsT-cell EpitopesTrypanosoma Cruzi InfectionTrypanosoma-induced T Cell ResponsesTrypanosomatid-host Interactions
The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naïve mice. In contrast, in vaccinated mice, the swift CD8+-T-cell response helps host survival after challenge.
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Susceptibility of β2-microglobulin-deficient mice to Trypanosoma cruzi infection
Rick L. Tarleton, Beverly H. Koller, A M Latour et al. · Nature · 1992 · 327 citations