Clinical Infectious Diseases · 2009 · 111 citations · 9 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesInflammationMedical MicrobiologyBacterial InfectionsImmune Responses To InfectionImmunocompromised Host InfectionsImmunodeficiency DisordersInfectious InflammationInflammation In Infectious DiseaseAids-defining InfectionsCryptococcal MeningitisFungal MeningitisHighly Active Antiretroviral TherapyHiv Antiretroviral TherapyImmune Reconstitution After Antiretroviral TherapyImmune Reconstitution SyndromeMulticenter Trials
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
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Samuel A. Shelburne, Jorge Darcourt, A. Clinton White et al. · Clinical Infectious Diseases · 2005 · 308 citations