Science · 1963 · 349 citations · 12 references
Life SciencesGeneticsMicrobiologyMicrobial GeneticsRadiation BiophysicsRadiobiologyBiological Effects Of RadiationDna ChemistryDna DamageNucleic Acid SynthesisRadiation ResistanceUltraviolet Radiation BiologyDna Synthesis InhibitionIonizing IrradiationMicrobial Adaptation To Ultraviolet RadiationRadiation-induced Dna DamageRadiation-resistant MicrobiologyUltraviolet IrradiationUltraviolet Light TreatmentUltraviolet-induced Dna Damage
Measurements of the inhibition of DNA synthesis in bacteria and the formation of thymine dimers by ultraviolet irradiation of the cells indicate that one thymine dimer per 350-IA strand of DNA acts as a block to further synthesis. In a sensitive strain of Escherichia coli the blocks are permanent. In a resistant strain the blocks are only temporary but recovery of synthesis is not the result of splitting dimers.
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