Imidazolyl Cyclodextrins: Artificial Serine Proteases Enabling Regiospecific Reactions

Abstract

Remote control: The imidazolyl group in a series of imidazolyl cyclodextrins guides the sulfonylation of a specific hydroxy group in the presence of many others to effect a regioselective 1,22 remote functionalization (see structure; Mess=mesitylenesulfonyl, n=0–2). This process enables the establishment of a novel efficient strategy for the hetero-bifunctionalization and -trifunctionalization of cyclodextrins. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701156_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.