Concepedia

α‐Alkylation of Carbonyl Compounds by Direct Addition of Alcohols to Enol Acetates

Yoshihiro Nishimoto, Yoshiharu Onishi, Makoto Yasuda, Akio Baba

Angewandte Chemie International Edition · 2009 · 63 citations · 43 references

DOI

Concepts

Abstract

A practical α-alkylation of ketones and aldehydes has been achieved by the direct addition of alcohols to enol acetates. The moderate Lewis acidity of InI3, GaBr3, and FeBr3 is a key factor in the catalytic cycle, and many different alcohols and enol acetates have been successfully used in this procedure.

References

43

Alcohols as Electrophiles in CC Bond‐Forming Reactions: The Hydrogen Autotransfer Process

Gabriela Guillena, Diego J. Ramón, Miguel Yus · Angewandte Chemie International Edition · 2007 · 558 citations

, , +15

(π-Allyl)palladium Complexes Bearing Diphosphinidenecyclobutene Ligands (DPCB):  Highly Active Catalysts for Direct Conversion of Allylic Alcohols

Fumiyuki Ozawa, Hideyuki Okamoto, Seiji Kawagishi et al. · Journal of the American Chemical Society · 2002 · 376 citations

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Direct Carbon–Carbon Bond Formation from Alcohols and Active Methylenes, Alkoxyketones, or Indoles Catalyzed by Indium Trichloride

Makoto Yasuda, Toshio Somyo, Akio Baba · Angewandte Chemie International Edition · 2005 · 306 citations

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Gold(III)-Catalyzed Nucleophilic Substitution of Propargylic Alcohols

Marie Georgy, Valérie Boucard, Jean‐Marc Campagne · Journal of the American Chemical Society · 2005 · 300 citations · Full text

, , +13

Organocatalytic Asymmetric Alkylation of Aldehydes by S<sub>N</sub>1‐Type Reaction of Alcohols

Pier Giorgio Cozzi, Fides Benfatti, Luca Zoli · Angewandte Chemie International Edition · 2009 · 256 citations · Full text

, , +6