A High Frequency of Activating Extracellular Domain <i>ERBB2</i> ( <i>HER2</i> ) Mutation in Micropapillary Urothelial Carcinoma

Abstract

NGS of MPUC revealed a high incidence of mutation in the extracellular domain of ERBB2, a gene for which there are five approved targeted therapies. NGS can identify genomic alteration, which inform treatment options for the majority of MPUC patients.