Concepedia

<i>Drosophila</i> Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility

Samantha Tirmarche, Shuhei Kimura, Laure Sapey-Triomphe, William Sullivan, Frédéric Landmann, Benjamin Loppin

G3 Genes Genomes Genetics · 2014 · 38 citations · 13 references

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Abstract

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.

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