Cu_2–<i>x</i>Se Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping

Abstract

The promise of a new nanomaterial, Cu2–xSe nanocrystals, as a contrast agent for photoacoustic imaging is demonstrated. The Cu2–xSe nanocrystals exhibit strong optical absorption at near infrared wavelengths that can efficiently penetrate tissue. In vivo photoacoustic tomography using this nanomaterial as the contrast agent provides clear three-dimensional resolution of a sentinel lymph node in a rat model. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.