Integrative Conjugative Elements and Related Elements Are Major Contributors to the Genome Diversity of<i>Streptococcus agalactiae</i>

Abstract

Thirty-five putative integrative conjugative elements and related elements were identified at 15 locations in the eight sequenced genomes of Streptococcus agalactiae. Twelve are composite, likely resulting from site-specific accretions. Circular forms were detected for five elements. Macroarray analysis confirmed their high plasticity and wide distribution in S. agalactiae.