Concepedia

Further characterization of borderline methicillin-resistant Staphylococcus aureus and analysis of penicillin-binding proteins

Maria Pia Montanari, Elena Tonin, Francesca Biavasco, Pietro E. Varaldo

Antimicrobial Agents and Chemotherapy · 1990 · 67 citations · 11 references

DOI

Concepts

Abstract

Eighty-nine Staphylococcus aureus strains were grouped according to their susceptibility or resistance to methicillin and oxacillin. The role of beta-lactamase in borderline methicillin resistance was confirmed by tests with beta-lactamase inhibitors, particularly when salt-supplemented medium was used. A penicillin-binding protein assay indicated that borderline methicillin-resistant S. aureus strains do not produce PBP 2a.

References

11

Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

Barry J. Hartman, Alexander Tomasz · Journal of Bacteriology · 1984 · 882 citations · Full text

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Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus

Yukio Utsui, Takeshi Yokota · Antimicrobial Agents and Chemotherapy · 1985 · 366 citations · Full text

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The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins

Linda K. McDougal, Clyde Thornsberry · Journal of Clinical Microbiology · 1986 · 329 citations · Full text

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Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus

Barry J. Hartman, Alexander Tomasz · Antimicrobial Agents and Chemotherapy · 1986 · 264 citations · Full text

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Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin.

Henry F. Chambers, Barry J. Hartman, Alexander Tomasz · Journal of Clinical Investigation · 1985 · 109 citations · Full text

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