Conjugated Oligoelectrolyte Harnessed Polyhedral Oligomeric Silsesquioxane as Light‐Up Hybrid Nanodot for Two‐Photon Fluorescence Imaging of Cellular Nucleus

Abstract

A water-soluble organic/inorganic hybrid nanodot based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte is designed and synthesized for two-photon fluorescence imaging of cellular nucleus, which takes advantage of its small size (∼3.3 nm) that imparts nucleus permeability and substantial DNA-enhanced two-photon excited fluorescence that allows illuminating the nucleus with a high contrast.