Physics in Medicine and Biology · 1988 · 2.2K citations · 17 references
Natural SciencesBiophysicsPhysicsBiomedical OpticsOpticsSpectroscopyLight-tissue InteractionOptical MetrologyOptical SpectroscopyScattering In TissueTissue Optical PropertiesTissue OpticsLight Scattering In TissueOptical Characterization Of Biological TissueOptical Scattering In TissueSpectroscopic QuantificationSpectroscopic Tissue Characterization
Quantitation of near‑infrared spectroscopic data in scattering tissues requires knowledge of the optical pathlength. The study demonstrates that the optical pathlength can be directly estimated from the time of flight of picosecond light pulses. Monte Carlo simulations and phantom experiments show that the mean time‑dispersed pulse correlates with the pathlength used in spectroscopic calculations, and time‑of‑flight measurements across a rat head yield a pathlength of 5.3 ± 0.3 times the head diameter.
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations. This result has been verified in a phantom material. Time of flight measurements of pathlength across the rat head give a pathlength of 5.3+or-0.3 times the head diameter.
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Susan Wray, Mark Cope, David T. Delpy et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 1988 · 914 citations
Methods of Quantitating Cerebral Near Infrared Spectroscopy Data
M. Cope, David T. Delpy, E. O. R. Reynolds et al. · Advances in experimental medicine and biology · 1988 · 506 citations
Medicine, Neurobiology, Neuroscience +12