ChemMedChem · 2011 · 33 citations · 54 references
MedicineMedicinal ChemistryPharmacologyAntimicrobial PharmacologyEnzymologyStructure-activity RelationshipsAntibacterial AgentsAntibacterial PharmacologyDrug-metabolizing EnzymesEnzyme ActivatorsEnzyme FunctionEnzyme InhibitionAminoglycoside AntibioticsAminoglycoside-modifying EnzymesAntibiotic Inactivating EnzymesAntibiotic Mechanisms Of ActionAntibiotic-modifying EnzymesEnzyme Inhibition Modulation
Paromomycin analogue activity: Novel amphiphilic aminoglycosides are shown to inhibit clinically relevant deactivating enzymes, without undergoing significant deactivation themselves.
54