Listeria monocytogenes Sequence Type 6 and Increased Rate of Unfavorable Outcome in Meningitis: Epidemiologic Cohort Study

Abstract

The rate of unfavorable outcome among adults with listerial meningitis has increased over a 14-year period, from 27% to 61%. The emerging L. monocytogenes genotype ST6 was identified as the main factor leading to poorer prognosis. Adjunctive dexamethasone may be discontinued if L. monocytogenes is identified, as there is no proven benefit in Listeria meningitis.