Acta Neurologica Scandinavica · 1971 · 60 citations · 20 references
Veterinary MedicinePharmacologyPhysiologyAnesthesiaGeneral AnesthesiaMetabolic PhysiologyAcid-base ManagementBrain Energy MetabolismCardiovascular Effects Of AnesthesiaHemodynamic Response To AnesthesiaAnaesthetic Effects On Cerebral PhysiologyBarbiturate AnesthesiaBarbiturate TherapyCerebral Energy FailureHemodynamic Effects Of AnesthesiaLactate ElevationPhysiologic Effects Of AnesthesiaPyruvate Metabolism
The influence of barbiturate anaesthesia upon the energy and acid-base metabolism of the brain was studied in arterial hypotension and in asphyxia by measuring the tissue concentrations of phosphocreatine, ATP, ADP, AMP, lactate, pyruvate, and bicarbonate. Intracellular lactate and pyruvate concentrations were derived after corrections for the lactate and pyruvate contained in the blood and extracellular fluid volumes of the tissue. Barbiturate anaesthesia was found to have a protective effect during arterial hypotension but not during total asphyxia.
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