Solid‐Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis

Abstract

Two's compliment: Solid-phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and SPME detects semi hydrophobic and hydrophobic compounds, including lipids related to neurodegenerative diseases. RT=retention time.