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Molecular Basis of Pathogenicity in <i>Helicobacter pylori</i> Clinical Isolates

Ivy Bastos Ramis, Tesiê Leopoldo Fonseca, Ernani Pinho de Moraes, Márcia Silveira Fernandes, Raúl Andrés Mendoza-Sassi, Obirajara Rodrigues, Carlos Renan Varela Juliano, Carlos James Scaini, Pedro Eduardo Almeida da Silva

Journal of Clinical Microbiology · 2010 · 16 citations · 27 references

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Abstract

This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.

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