Revisiting the Central Dogma in the 21st Century

TLDR

The central dogma has been reshaped by discoveries of interactive multimolecular execution, modular organization, hierarchical control, and an informatic view of genome function, challenging atomistic pre‑DNA ideas. The informatic perspective motivates novel concepts of cellular cognition, molecular representations of physiological states, genome system architecture, and algorithmic genome expression and restructuring. These discoveries contradict atomistic pre‑DNA ideas of genome organization and violate the central dogma at multiple points.

Abstract

Since the elaboration of the central dogma of molecular biology, our understanding of cell function and genome action has benefited from many radical discoveries. The discoveries relate to interactive multimolecular execution of cell processes, the modular organization of macromolecules and genomes, the hierarchical operation of cellular control regimes, and the realization that genetic change fundamentally results from DNA biochemistry. These discoveries contradict atomistic pre‐DNA ideas of genome organization and violate the central dogma at multiple points. In place of the earlier mechanistic understanding of genomics, molecular biology has led us to an informatic perspective on the role of the genome. The informatic viewpoint points towards the development of novel concepts about cellular cognition, molecular representations of physiological states, genome system architecture, and the algorithmic nature of genome expression and genome restructuring in evolution.