Deletion of the α1 or β2 Subunit of GABAAReceptors Reduces Actions of Alcohol and Other Drugs

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

Dolan B. Pritchett, Harald Sontheimer, Brenda D. Shivers et al. · Nature · 1989 · 1.3K citations

Molecular Pharmacology, Benzodiazepine Pharmacology, Medicine +8

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

Elizabeth M. Simpson, C. Linder, Evelyn E. Sargent et al. · Nature Genetics · 1997 · 696 citations

Knockout Mouse, Engineering, Genetic Disorder +11

Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

Robert Mihalek, Pradeep Banerjee, Esa R. Korpi et al. · Proceedings of the National Academy of Sciences · 1999 · 525 citations · Full text

Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Ulrich L. Günther, Jack A. Benson, Dietmar Benke et al. · Proceedings of the National Academy of Sciences · 1995 · 444 citations · Full text

Neurotransmitter, Experimental Pharmacology, Social Sciences +20

Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression.

Alison Jones, Esa R. Korpi, Ruth M. McKernan et al. · PubMed · 1997 · 320 citations · Full text

Gabaa Receptor Subunits, Molecular Physiology, Signal Transduction +14