EFFECTS OF ISOPROTERENOL ON SPONTANEOUS EXCITATIONS IN DETRUSOR SMOOTH MUSCLE CELLS OF THE GUINEA PIG

Abstract

Our results suggest that isoproterenol prevented spontaneous action potential discharges and associated calcium transients through the activation of protein kinase A. The isoproterenol induced inhibition of intracellular Ca(2+) largely depends on the prevention of spontaneous action potentials since the contribution of the intracellular calcium store was small. Isoproterenol hyperpolarizes the membrane, probably by stimulating sodium pump activity.