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Effect of CNS-Depressants, Dexamethasone and Growth Hormone on the Response to Growth Hormone-Releasing Factor
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1967
Year
Human GrowthNeuroendocrinologyGrowth Hormone-releasing FactorGlucocorticoidReproductive EndocrinologyMolecular PharmacologyPituitary GlandDirect ActionNeuroendocrine MechanismPrevented DepletionHealth SciencesGrowth HormoneStress HormonePsychiatryEndocrine MechanismDepressionNeuropharmacologyDevelopmental EndocrinologyNervous SystemEndocrinologyPharmacologyPhysiologyReceptor BiologyMood DisordersNeuroscienceCentral Nervous SystemMedicine
Highly purified growth hormonereleasing factor (GRF) was given to rats; pretreated with reserpine, chlorpromazine, pentobarbital-morphine, dexamethasone and growth hormone (GH). Only the last named prevented depletion of GH in the recipients’ pituitaries. This may suggest that GRF releases GH by a direct action on the pituitary and that the level of GH in blood may be a factor taking part either directly or indirectly in regulating release of GH from the pituitary. (Endocrinology81: 1410,1967)