Concepedia

Generation and Characterization of a Defined Mutant of <i>Streptococcus suis</i> Lacking Suilysin

Andrew G. Allen, Steven Bolitho, Heather Lindsay, Shahid A. Khan, Clare Bryant, Philip N. Ward, James A. Leigh, Jeremy Morgan, Helen Riches, Sarah Eastty,

Infection and Immunity · 2001 · 85 citations · 14 references

DOI

Concepts

Abstract

A defined allelic-replacement mutant of the sly gene, encoding a thiol-activated cytolysin, from a European isolate of Streptococcus suis serotype 2 was generated and characterized. Unlike the parental strain, it is nonhemolytic, noncytotoxic for cultured macrophage-like cells, avirulent in a mouse infection model, yet only slightly attenuated in a porcine model of systemic infection.

References

14

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Linda Reed, Hugo Muench · American Journal of Epidemiology · 1938 · 20.2K citations

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A simple method of estimating 50 per cent end points

Hr Muench · Medical Entomology and Zoology · 1938 · 8.4K citations

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The Relative Role of Bacterial Cell Wall and Capsule in the Induction of Inflammation in Pneumococcal Meningitis

Elaine Tuomanen, Alexander Tomasz, B. Hengstler et al. · The Journal of Infectious Diseases · 1985 · 236 citations · Full text

, , +17

Identification, purification, and characterization of a thiol-activated hemolysin (suilysin) of Streptococcus suis

A. A. Jacobs, P L Loeffen, A J van den Berg et al. · Infection and Immunity · 1994 · 187 citations · Full text

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<i>Streptococcus suis</i> Serotype 2 Interactions with Human Brain Microvascular Endothelial Cells

Nathalie Charland, Victor Nizet, Craig E. Rubens et al. · Infection and Immunity · 2000 · 149 citations · Full text

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