The Mechanism of Histamine Release in Anaphylactic Reaction in Guinea Pig and Rat

Abstract

Abstract C hakravarty , N. The mchanism of histamine release in anaphylactic reaction in guinea pig and rat. The mechanism of histamine release was studied in anaphylactic reaction in vitro in tissues from guinea pig and rat; it was compared, in rat, with histamine release induced by compound 48/80. The observations suggest that histamine release in both species is mediated by the activation of an enzyme system probably with essential sulphydryl and amino groups. Histamine release in anaphylaxis and that induced by compound 48/80 in rat appear to be mediated by the same mechanism. Some differences were observed in anaphylactic histamine release in the two species: anoxia inhibited histamine release in guinea‐pig tissue but not in rat tissue; the same was true of two triphenylmethane dyes. Despite these differences, anaphylactic histamine release in the two species seems to follow, on the whole, a common pathway.