Dietary Omega-3 Fatty Acids, <i>Cyclooxygenase-2</i> Genetic Variation, and Aggressive Prostate Cancer Risk

Abstract

Dietary LC n-3 polyunsaturated fatty acids appear protective for aggressive prostate cancer, and this effect is modified by the COX-2 SNP rs4648310. Our findings support the hypothesis that LC n-3 may impact prostate inflammation and carcinogenesis through the COX-2 enzymatic pathway.