Modulation of chondrocyte synthesis by lymphokine-rich conditioned media

Abstract

The pathophysiologic significance of T cell factors has been studied in relation to T cell capacity to quantitatively modulate chondrocyte synthesis. Lymphokine-rich supernates derived from normal human peripheral blood mononuclear cells have been shown to suppress chondrocyte glycosaminoglycan, protein, collagen, and nucleic acid synthesis, whether assessed in cartilage organ or chondrocyte suspension culture systems. A compartmental redistribution of newly synthesized glycosaminoglycan and protein was observed between the chondrocyte, its cell layer, and that released into culture supernates.