Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Knockout Mouse, Spontaneous Tumours, Medicine +9

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Tobias Sjöblom, Siân Jones, Laura D. Wood et al. · Science · 2006 · 3.2K citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

Nutrient-sensitive Complex, Cell Growth Machinery, Signal Transduction +12

The Genomic Landscapes of Human Breast and Colorectal Cancers

Laura D. Wood, D. Williams Parsons, Siân Jones et al. · Science · 2007 · 2.8K citations

Engineering, Genetics, Genomics +16

Activating Mutations of <i>NOTCH1</i> in Human T Cell Acute Lymphoblastic Leukemia

Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee et al. · Science · 2004 · 2.7K citations

Hematological Malignancy, Human T-all, Activated Notch1 +13