Concepedia

Synthetic double-stranded RNA induces interleukin-32 in bronchial epithelial cells

Kyoko Ota, Mio Kawaguchi, Jun‐ichi Fujita, Fumio Kokubu, Shau-Ku Huang, Yuko Morishima, Satoshi Matsukura, Masatsugu Kurokawa, Yukio Ishii, Hiroaki Satoh,

Experimental Lung Research · 2015 · 16 citations · 28 references

DOI

Abstract

The expression of IL-32 is induced by dsRNA via the TAK1-NF-κB signaling pathway in bronchial epithelial cells. IL-32 is involved in the pathogenesis of airway inflammation, and may be a novel therapeutic target for airway inflammatory diseases.

References

28

Interleukin-32

Soo Hyun Kim, Sun-Young Han, Tania Azam et al. · Immunity · 2005 · 534 citations · Full text

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

Elena Goleva, Leisa Jackson, J. Kirk Harris et al. · American Journal of Respiratory and Critical Care Medicine · 2013 · 357 citations · Full text

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1β and IL-6 production through a caspase 1-dependent mechanism

Mihai G. Netea, Tania Azam, Gerben Ferwerda et al. · Proceedings of the National Academy of Sciences · 2005 · 288 citations

Identification of a novel gene expressed in activated natural killer cells and T cells

Carol Dahl, Rebecca P. Schall, Hailan He et al. · The Journal of Immunology · 1992 · 205 citations

Requirement for Both JAK-Mediated PI3K Signaling and ACT1/TRAF6/TAK1-Dependent NF-κB Activation by IL-17A in Enhancing Cytokine Expression in Human Airway Epithelial Cells

Fei Huang, Cheng–Yuan Kao, Shinichiro Wachi et al. · The Journal of Immunology · 2007 · 205 citations