Studies of the Effect of Vanadium on Chick Growth

Abstract

PROESCHER and Seil (1917) observed that vanadium was toxic to mice, rats, guinea pigs and rabbits. Since then numerous investigators have reported on the adverse effects of this element when ingested by various mammalian species. Some of the effects of vanadium poisoning have been reviewed by Patty (1949). The heart, kidneys, lungs, spleen and central nervous system all have been shown to be affected. Romoser et al. (1960), appear to be the first to show that vanadium retards the growth rate of chicks. One of the primary modes of action of vanadium apparently is its ability to affect the reactions of sulfur-containing compounds. Mountain et al. (1953) reported a reduction in the cystine content of the hair of rats fed diets containing as little as 0.01% vanadium. Higher levels reduced body weight gains but could be counteracted by the administration of methionine. Mascitelli-Coriandoli and Citterio (1959a, b) presented evidence to …