5(4<i>H</i>)‐Oxazolones as Intermediates in the Carbodiimide‐ and Cyanamide‐Promoted Peptide Activations in Aqueous Solution

Abstract

The early days: although considered a species to be avoided in peptide chemistry, the intermediacy of 5(4H)-oxazolones is demonstrated to be essential for the formation of peptides through cyanamide and carbodiimide activation in aqueous solution.